Endocrine Abstracts

Measurement of the various available bone formation and resorption markers provide insights into different aspects of the bone metabolism process. Interpretation of bone biomarkers in a clinical setting is complex. Analysis of formation markers including bone alkaline phosphatase, procollagen type 1 propeptide and intact osteocalcin and resorption markers including free deoxypyridinoline and N-terminal cross-linking telopeptide of type 1 collagen were performed. From the inter...

Introduction: Osteoporosis is an important cause of morbidity and mortality in older men, but the extent of the problem amongst Emiratis has not been previously reported. A screening programme has been in place for older men in a large diabetes centre in the UAE, allowing patients over age 70 to have DEXA scans; we have investigated the prevalence of osteoporosis and osteopenia in this population.Methods: Data on 179 consecutive patients with type 2 diab...

Background and objectives: Non-alcoholic fatty liver disease (NAFLD) is highly prevalent in patients with diabetes as well as the vice versa. It is crucial to identify the characteristics of this group of patients in order to prevent the development, the progression as well as the complications of the disease. We have studied characteristics of patients having both NAFLD and diabetes who are attending a tertiary care institute in Sri Lanka.Methods: A des...

Background and aims: GLP1 agonists are used in UAE for diabetes and obesity management (prevalence of 19 and 74% respectively). Few outcome data on GLP1 agonist therapy in this population is available. We investigated the effects of two commonly used GLP1 agonists on weight and HbA1c among UAE patients with diabetes.Materials and methods: Data was retrieved from a computerized database of patients attending a large diabetes center in UAE. Patients on exe...

Background: LHX4 encodes a member of the LIM-homeodomain transcription factor protein family that is required for development of the pituitary gland. To date, only incompletely penetrant heterozygous mutations in LHX4 have been described in patients with variable combined pituitary hormone deficiencies (CPHD).Objective/hypothesis: To investigate a cohort of patients with congenital hypopituitarism for mutations in LHX4.<p c...

Case report: 24-year. old man presented with change in facial appearance and joint pain. His symptoms began at puberty with the thickening and folding of the skin on the forehead and scalp and thickening of his fingers. These changes progressed over the next 5 years with marked seborrhoea, hyperhidrosis and linear palmar–plantar keratosis. The lower legs and forearms are cylindrically thickened, hands and feet increased in size, the terminal phalanges of the fingers show ...

Introduction: Several studies have examined the association of the common PvuII polymorphism of the estrogen receptor alpha (ERα) gene with the risk of stroke. Data linking the polymorphism with the severity and outcome of cerebrovascular disease is lacking. We looked for possible associations of the PvuII polymorphism with stroke severity and short-term prognosis in a cohort of female stroke patients.Patients-Methods: We studied 302 postmenopausal ...

Hyperprolactinemia may cause bone loss in pre-menopausal women and men. Data on fractures are scanty and it is still unclear which is the skeletal impact of hyperprolactinemia in post-menopausal women. The aim of this study was to evaluate the prevalence of vertebral fractures in post-menopausal women with hyperprolactinemia.Forty post-menopausal women (median age 57 years, range: 47–81) with prolactin (PRL)-secreting adenoma and 119 control post-me...

Low vitamin D levels have been found in patients with diabetes mellitus type 2 and have been correlated with poor glycemic control. There are observations suggesting that vitamin D levels may be low in obesity.The aim was to study vitamin D levels in obese individuals.The levels of 25(OH)D3 were measured in 30 obese individuals aged 42.67 years (mean), range 27–64, BMI 35.49 (mean), range 30–46 and 37 control s...

Introduction: The clinical significance of subclinical thyroid diseases is debated.Design: To assess the relationship between undiagnosed subclinical hypothyroidism (USH), health indicators (HI) and cardiovascular risk factors (CVRF), this cross-sectional study was conducted in 1100 adults representatives of non-institutionalized Catalan population (44.5% men; mean age: 44.8±15.2 years) in Catalonia (Spain); 40 USH (18 men) and 1060 euthyroid (474 m...